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Potency and stability of compounded cyclophosphamide: a pilot study.
1Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Veterinary and Comparative Oncology
|March 31, 2016
Summary
Compounded veterinary oncology drugs, specifically cyclophosphamide capsules, showed concerning potency issues in a pilot study. Stability was generally good, but further research and collaboration are needed for safe drug delivery.
Area of Science:
- Veterinary Pharmacology
- Compounded Medications
- Oncology Drug Analysis
Background:
- Compounding of drugs for veterinary oncology is a growing practice.
- Ensuring the quality and accuracy of compounded medications is crucial for patient safety.
Purpose of the Study:
- To evaluate the potency and stability of compounded cyclophosphamide capsules for veterinary use.
- To identify potential quality control issues in veterinary drug compounding.
Main Methods:
- Obtained 15 mg cyclophosphamide capsules from five compounding pharmacies.
- Performed potency analyses at two time points.
- Assessed drug stability over 60 days.
Main Results:
- Potency results were inadequate for 4 out of 10 analyzed samples (four out of five pharmacies).
- Stability at 60 days was acceptable for all but one sample.
- The study highlights significant concerns regarding the quality of compounded chemotherapy drugs.
Conclusions:
- Pilot study indicates potential issues with potency in compounded veterinary oncology drugs.
- Further studies are required to validate these findings.
- Collaboration among pharmacists, veterinarians, and regulatory bodies is essential for ensuring safe and accurate compounded drug delivery in animals.
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