Functional and morphological alterations of the urinary bladder in type 2 diabetic FVB(db/db) mice
Liyang Wu1, Xiaodong Zhang2, Nan Xiao3
1Department of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA; Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, PRC.
Journal of Diabetes and Its Complications
|April 3, 2016
Summary
This study reveals type 2 diabetes in FVB(db/db) mice causes diabetic bladder dysfunction (DBD) with increased bladder capacity and pressure. These mice offer a valuable model for studying diabetes-related bladder issues.
Area of Science:
- Urology
- Endocrinology
- Diabetology
Background:
- Diabetic bladder dysfunction (DBD) is a known complication of diabetes.
- Most research focuses on type 1 diabetes models.
- Type 2 diabetes (T2D) related DBD mechanisms require further investigation.
Purpose of the Study:
- To investigate functional and morphological changes in the urinary bladder of a type 2 diabetes mouse model (FVB(db/db)).
- To assess bladder alterations at different stages of type 2 diabetes progression.
Main Methods:
- FVB(db/db) mice and controls were studied at 12, 24, and 52 weeks.
- Evaluated body weight, blood glucose, and HbA1c.
- Assessed 24-h urination, conscious cystometry, and performed morphometric analysis.
Main Results:
- FVB(db/db) mice showed increased body weight and altered glucose/HbA1c levels.
- Bladder function analysis revealed increased voided volume, bladder capacity, and micturition pressure.
- Morphometric analysis indicated increased detrusor muscle and urothelium areas, with some mice exhibiting detrusor overactivity.
Conclusions:
- The FVB(db/db) mouse model exhibits significant diabetic bladder dysfunction.
- This model demonstrates increased bladder capacity, voided volume, micturition pressure, and overactivity.
- FVB(db/db) mice are a suitable model for studying type 2 diabetes-related bladder dysfunction mechanisms.
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