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Related Concept Videos

Autophagy01:27

Autophagy

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Autophagic Cell Death01:18

Autophagic Cell Death

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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
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DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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DNA Damage can Stall the Cell Cycle02:36

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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Updated: Mar 23, 2026

Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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Purification of Ubiquitinated p53 Proteins from Mammalian Cells

Published on: March 21, 2022

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Autophagy and p53.

Eileen White1

  • 1Rutgers Cancer Institute of New Jersey (CINJ), New Brunswick, New Jersey 08903 Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854.

Cold Spring Harbor Perspectives in Medicine
|April 3, 2016
PubMed
Summary
This summary is machine-generated.

Macroautophagy (autophagy) and p53 have a reciprocal relationship. Autophagy suppresses p53, aiding tumor growth, while p53 activates autophagy, contributing to cellular protection. Understanding this interaction is key for disease treatment.

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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

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Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Macroautophagy (autophagy) is a fundamental cellular process for maintaining homeostasis.
  • Autophagy degrades and recycles intracellular components, ensuring protein and organelle quality control.
  • Autophagy plays a crucial role in survival during starvation and preventing tissue degeneration.

Purpose of the Study:

  • To investigate the complex reciprocal relationship between autophagy and the p53 protein.
  • To elucidate the mechanisms underlying the interplay between autophagy and p53.
  • To explore the implications of this interaction for human diseases and therapeutic strategies.

Main Methods:

  • The study likely involved molecular biology techniques to analyze protein interactions and cellular pathways.
  • Investigated the functional consequences of modulating autophagy and p53 levels.
  • Utilized cell-based assays and potentially in vivo models to study autophagy-p53 dynamics.

Main Results:

  • Demonstrated a dual role for autophagy in relation to p53: suppression and activation.
  • Autophagy-mediated suppression of p53 is linked to tumor promotion and tissue degeneration.
  • p53-induced autophagy activation suggests a role in cellular protective mechanisms.

Conclusions:

  • The reciprocal interaction between autophagy and p53 is critical for cellular functions.
  • Understanding the mechanisms of this interaction has significant implications for developing treatments for various human diseases.
  • Targeting the autophagy-p53 axis may offer novel therapeutic avenues.