Related Experiment Video
Updated: Mar 23, 2026
09:06
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
491
MicroRNAs in Myeloid Hematological Malignancies
Maria Ciccone1, George Adrian Calin1
1Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Current Genomics
|April 6, 2016
Summary
MicroRNAs (miRNAs) are key regulators in myeloid malignancies. Dysregulated miRNA expression contributes to leukemic transformation, and miRNA-targeted therapies show promise for treating these hematological disorders.
Area of Science:
- Molecular Biology
- Hematology
- Oncology
Background:
- Myeloid malignancies encompass diverse disorders of hematopoietic stem cells.
- Genetic abnormalities like t(9;22) are hallmarks, but molecular mechanisms remain unclear in many cases.
- MicroRNAs (miRNAs) are noncoding RNAs regulating gene expression.
Purpose of the Study:
- To explore the role of miRNAs in myeloid malignancies.
- To investigate the diagnostic and therapeutic potential of miRNAs in these cancers.
Main Methods:
- Analysis of miRNA expression levels in patients versus healthy individuals.
- In vitro experiments and pre-clinical models to assess miRNA function.
- Review of existing literature on miRNA involvement in leukemogenesis.
Main Results:
- Specific miRNA expression levels differ between myeloid malignancy patients and healthy controls.
- MiRNAs partially elucidate the mechanisms of leukemic transformation.
- Preliminary data suggest safety and efficacy of miRNA inhibitory molecules.
Conclusions:
- MiRNAs are implicated in the pathogenesis of myeloid malignancies.
- MiRNA expression profiling may aid in diagnosis and prognosis.
- miRNA-based therapeutics represent a novel treatment strategy for myeloid cancers.
Related Concept Videos
01:22MicroRNAs
4.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
01:22MicroRNAs
24.6K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.6K
01:22MicroRNAs
12.0K
12.0K
02:23Abnormal Proliferation
5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
02:39lncRNA - Long Non-coding RNAs
10.1K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.1K