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MicroRNAs in Lymphoma: Regulatory Role and Biomarker Potential

Marta Fernandez-Mercado1, Lorea Manterola1, Charles H Lawrie2

  • 1Oncology area, Biodonostia Research Institute, San Sebastián, Spain;

Current Genomics
|April 6, 2016
PubMed

Insights

MicroRNAs (miRNAs) are short non-coding RNAs regulating gene control, vital in lymphoid biology and cancer. This review explores their role in lymphopoiesis, lymphomagenesis, and potential as biomarkers and therapeutics.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are short, non-coding RNA molecules.
  • They have emerged as critical regulators in physiological and pathological processes, including cancer.
  • Their formal recognition is less than 15 years old.

Purpose of the Study:

  • To review the role of miRNAs in lymphoid biology.
  • To discuss miRNAs in lymphopoiesis and lymphomagenesis.
  • To explore their utility as biomarkers and therapeutics for lymphoma.

Main Methods:

  • Literature review focusing on miRNA function in lymphoid systems.
  • Analysis of miRNA expression in physiological and malignant conditions.
  • Examination of current and potential clinical applications.

Main Results:

  • Aberrant miRNA expression is significant in lymphomas.
  • miRNAs show potential as both in situ and non-invasive biomarkers.
  • miRNAs are being investigated as therapeutic agents for lymphoma.

Conclusions:

  • miRNAs represent a new paradigm in gene regulation.
  • They hold significant promise as diagnostic biomarkers for lymphoma.
  • Further research is needed to overcome hurdles for therapeutic translation in clinical practice.
Keywords:
BiomarkerHematological malignanciesLymphoidLymphomamicroRNAncRNA.

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