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Carrageenan-induced acute inflammatory response in chicks
N M Ito1, A M Noronha, G M Bohm
1Faculdade de Medicina Veterinária e Zootecnica da USP, Departamento de Patologia-Ornitopatologia, Sao Paulo, Brazil.
Research in Veterinary Science
|March 1, 1989
Summary
Carrageenan induced acute inflammation in chickens, primarily mediated by histamine and serotonin. This model showed less severe edema than turpentine, with prostaglandins playing a minor role.
Area of Science:
- Pharmacology
- Immunology
- Veterinary Medicine
Background:
- Acute inflammation models are crucial for studying inflammatory mediators.
- Carrageenan is a common agent used to induce experimental inflammation.
Purpose of the Study:
- To investigate the inflammatory response induced by carrageenan in chickens.
- To identify the primary mediators involved in carrageenan-induced inflammation in this model.
Main Methods:
- Acute inflammatory response evoked in chicken foot pads using carrageenan.
- Administration of histamine, serotonin, and prostaglandin antagonists.
- Evaluation of edema formation and vascular permeability.
- Assessment of the effect of Bothrops jararaca venom.
Main Results:
- Carrageenan induced a monophasic, short-duration inflammatory response.
- Histamine and serotonin were identified as key mediators, as antagonists reduced inflammation.
- Prostaglandins played a minor role, with indomethacin only affecting the later phase of edema.
- Bothrops jararaca venom did not potentiate the response, suggesting bradykinin was not a significant mediator.
Conclusions:
- Carrageenan-induced inflammation in chickens is primarily mediated by histamine and serotonin.
- This model is less severe than turpentine-induced inflammation.
- Prostaglandins and bradykinin appear to play minor roles in this specific inflammatory model.