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Updated: Mar 23, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact
Juan Ignacio Rojas1, Liliana Patrucco1, Jimena Miguez1
1Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano Buenos Aires, Buenos Aires, Argentina.
Abstract:
Multiple sclerosis (MS) was always considered as a white matter inflammatory disease. Today, there is an important body of evidence that supports the hypothesis that gray matter involvement and the neurodegenerative mechanism are at least partially independent from inflammation. Gray matter atrophy develops faster than white matter atrophy, and predominates in the initial stages of the disease. The neurodegenerative mechanism creates permanent damage and correlates with physical and cognitive disability. In this review we describe the current available evidence regarding brain atrophy and its consequence in MS patients.
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