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PDT Dose Dosimeter for Pleural Photodynamic Therapy
Michele M Kim1, Arash Darafsheh2, Mahmoud Ahmad2
1Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA.
Summary
A new photodynamic therapy (PDT) dosimeter measures light and photosensitizer levels simultaneously. This innovation enables accurate, real-time PDT dose delivery and improved treatment dosimetry for better patient outcomes.
Area of Science:
- Biomedical Engineering
- Optical Physics
- Photodynamic Therapy
Background:
- Photodynamic therapy (PDT) relies on accurate dosimetry, which is challenging due to the interplay of light fluence and photosensitizer concentration.
- Current dosimetry methods often measure these parameters separately or indirectly, leading to potential inaccuracies.
Purpose of the Study:
- To develop and validate a novel PDT dose dosimeter for simultaneous, real-time measurement of light fluence and photosensitizer concentration.
- To improve the accuracy and reliability of PDT dosimetry for enhanced treatment efficacy.
Main Methods:
- A PDT dose dosimeter was engineered to measure both light fluence and photosensitizer concentration concurrently at the treatment site.
- Light fluence measurements were validated against photodiode and multi-fiber spectroscopy.
- Photosensitizer concentration was determined by measuring laser-induced fluorescence, with phantom studies used for optical property correction.
Main Results:
- The developed dosimeter accurately measured light fluence and photosensitizer concentration simultaneously.
- Phantom studies provided optical property corrections for fluorescence-based concentration measurements.
- In vivo measurements in patients demonstrated the dosimeter's capability to assess dose heterogeneity within the pleural cavity.
Conclusions:
- The novel PDT dose dosimeter enables accurate, real-time determination of delivered PDT dose.
- This technology significantly improves PDT dosimetry, paving the way for more precise and effective photodynamic therapies.
