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Updated: Mar 22, 2026

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
Published on: March 10, 2016
[Epigenetics in allergic diseases and asthma]
José A Castro-Rodríguez1, Bernardo J Krause2, Ricardo Uauy1
1División de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Laboratorio de Programación y Epigenética Perinatal, Centro de Investigaciones Médicas, Santiago, Chile.
Abstract:
Allergic diseases and asthma are the result of complex interactions between genetic predisposition and environmental factors. Asthma is one of the most prevalent chronic disease among children. In this article we review some environmental factors like: allergen exposition, tobacco, bacteria, microbial components, diet, obesity and stress, which influences during intrauterine and infancy life in the epigenetic regulation of asthma and allergic diseases. The review has been done in three models: in-vitro, animal and human.
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