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Related Concept Videos

The Skin Microbiota01:27

The Skin Microbiota

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The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
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Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

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Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
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Microbiome of the Eye01:22

Microbiome of the Eye

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The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
4
The Oral Microbiota01:27

The Oral Microbiota

7
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

1
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
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Development of Human Microbiota01:30

Development of Human Microbiota

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The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
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Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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Skin Biomes.

N Fyhrquist1, A Salava2, P Auvinen3

  • 1Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.

Current Allergy and Asthma Reports
|April 9, 2016
PubMed
Summary
This summary is machine-generated.

The skin microbiome, a diverse community of microbes on human skin, is increasingly linked to skin disorders like atopic dermatitis. Understanding these microbial changes may offer new diagnostic and therapeutic strategies for inflammatory skin conditions.

Keywords:
Cutaneous microbial diversityInflammatory skin diseasesMetagenomicsSkin microbiomeStaphylococcus aureus

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Area of Science:

  • Microbiology
  • Dermatology
  • Human Microbiome

Background:

  • The human skin microbiome is a complex ecosystem with a significant role in skin health.
  • Traditional views are evolving regarding the skin's microbial inhabitants and their functions.
  • The skin microbiome's influence on pathogenic microbes and skin disorder progression is under active investigation.

Purpose of the Study:

  • To explore the connection between the cutaneous microbiome and skin disorders.
  • To highlight the potential of the skin microbiome as a diagnostic and therapeutic target.

Main Methods:

  • Review of recent research on the cutaneous microbiome.
  • Analysis of the relationship between microbial dysbiosis and inflammatory skin conditions.

Main Results:

  • Evidence suggests a link between skin disorders, such as atopic dermatitis, and dysbiosis of the skin microbial community.
  • Changes in the skin microbiome composition are associated with impaired skin barrier function and immune disturbances.

Conclusions:

  • The cutaneous microbiome plays a crucial role in modulating skin health and disease.
  • Investigating the skin microbiome offers promising avenues for novel diagnostic and therapeutic approaches in dermatology.