[Sinunasal Tumors]

Area of Science:

• Otolaryngology
• Head and Neck Surgery
• Oncology

Background:

• Sinunasal tumors are rare, heterogeneous lesions affecting the nose, sinuses, and skull base.
• These tumors exhibit diverse biological activities and clinical behaviors, necessitating tailored treatment strategies.
• Current treatment outcomes for sinunasal malignancies (SNM) show only modest improvements in overall survival.

Purpose of the Study:

• To highlight the need for more effective local and systemic treatments for sinunasal tumors.
• To explore novel multimodal treatment strategies for improving patient quality of life and survival.

Main Methods:

• Review of current treatment approaches for sinunasal tumors.
• Analysis of recent advancements in surgical techniques, chemoradiation, and antibody therapies.

Main Results:

• Despite advancements, overall survival for sinunasal malignancies remains moderate to low.
• Multimodal strategies integrating new surgical concepts, chemoradiation, and antibody treatments show promise.

Conclusions:

• There is a critical need for enhanced local and systemic treatment modalities for sinunasal tumors.
• Innovative multimodal treatment strategies offer potential for improved quality of life and survival in patients with sinunasal tumors.