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Effect of chloride on blood pressure and sympathetic nervous system activity in deoxycorticosterone acetate-treated
1First Department of Internal Medicine, Kobe University School of Medicine, Japan.
American Journal of Hypertension
|April 1, 1989
Abstract:
The effect of selective chloride loading on blood pressure and sympathetic nervous system activity was studied in deoxycorticosterone acetate (DOCA)-treated rats. The rats fed a normal sodium-high chloride and fed a high sodium chloride diet had higher blood pressure and lower cardiac norepinephrine concentrations than those fed a normal sodium chloride diet. Furthermore, cardiac norepinephrine concentrations were significantly correlated with systolic blood pressure. These data suggest that selective chloride loading can raise blood pressure in DOCA-treated rats due to augmented sympathetic nervous system activity.