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Surface antigen in early differentiation.

R Kemler, C Babinet, H Eisen

    Proceedings of the National Academy of Sciences of the United States of America
    |October 1, 1977
    PubMed
    Summary
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    Fab fragments targeting the F9 surface antigen block mouse embryo compaction and blastocyst formation. This effect is reversible, allowing normal development and live birth after Fab removal.

    Area of Science:

    • Developmental Biology
    • Cell Biology
    • Immunology

    Background:

    • Early mouse embryo development involves critical cell-cell interactions.
    • Surface antigens play roles in embryonic cell adhesion and compaction.

    Purpose of the Study:

    • To investigate the role of the F9 surface antigen in early mouse embryo development.
    • To determine the effects of inhibiting F9 antigen function on embryo compaction and blastocyst formation.

    Main Methods:

    • Culture of 2-cell stage mouse embryos with Fab fragments from anti-F9 antiserum.
    • Observation of effects on cleavage, compaction, and blastocyst formation.
    • Reversibility studies by washing out Fab fragments and assessing subsequent development.

    Main Results:

    Related Experiment Videos

    • Fab fragments targeting F9 antigen prevented compaction of 2-cell and 8-cell stage embryos.
    • Inhibition of compaction occurred without affecting initial cleavage stages.
    • Developmental block was reversible upon removal of Fab fragments, leading to blastocyst formation and live offspring.

    Conclusions:

    • The F9 surface antigen is crucial for cell adhesion and compaction in early mouse embryos.
    • Inhibition of F9 antigen function reversibly disrupts blastocyst formation.
    • These findings highlight the importance of specific surface antigens in mammalian embryonic development.