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Related Concept Videos

Bone Formation by Intramembranous Ossification01:29

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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Bone Formation by Endochondral Ossification01:24

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Spongy Bone01:09

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
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Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Related Experiment Video

Updated: Mar 22, 2026

Laminectomy for the Removal of Thoracic Ossification of the Ligamentum Flavum TOLF Using Ultrasonic and Conventional Osteotomes
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Diffuse pulmonary ossification: A case report.

Diogo Roriz1, Inês Abreu1, Cristina Marques1

  • 1Medical Imaging Department and Faculty of Medicine, University Hospital of Coimbra, Portugal, Praceta Mota Pinto/Av. Bissaya Barreto, 3000-075 Coimbra, Portugal.

European Journal of Radiology Open
|April 13, 2016
PubMed
Summary

Diffuse pulmonary ossification (DPO) is a rare lung condition. This case highlights DPO secondary to mitral stenosis, emphasizing its association with severe cardiac pathology.

Keywords:
CTDiffuse pulmonary ossificationHigh-resolutionMitral stenosis

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Area of Science:

  • Pulmonology
  • Radiology
  • Cardiology

Background:

  • Diffuse pulmonary ossification (DPO) is an uncommon condition.
  • It can present with distinct imaging findings on chest CT.
  • DPO is considered in the differential diagnosis of lung calcifications.

Observation:

  • A case of DPO secondary to mitral stenosis is presented.
  • The patient had severe cardiac pathology.
  • The patient died a few weeks after a chest CT scan.

Findings:

  • The case demonstrates a link between DPO and severe mitral stenosis.
  • Characteristic imaging features of DPO were identified.
  • No specific beneficial treatments for DPO are currently established.

Implications:

  • Radiologists should consider DPO when encountering lung parenchymal calcifications.
  • This case underscores the association between DPO and significant cardiac disease.
  • Further research may be needed to explore potential treatments for DPO.