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Updated: Mar 22, 2026

Characterizing Extracellular Vesicles from Biological Fluids
Published on: February 28, 2025
Illuminating the physiology of extracellular vesicles
Hongyoon Choi1,2, Dong Soo Lee3,4,5
1Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yongon-Dong, Jongno-Gu, Seoul, 110-744, South Korea.
Abstract:
Extracellular vesicles play a crucial role in intercellular communication by transmitting biological materials from donor cells to recipient cells. They have pathophysiologic roles in cancer metastasis, neurodegenerative diseases, and inflammation. Extracellular vesicles also show promise as emerging therapeutics, with understanding of their physiology including targeting, distribution, and clearance therefore becoming an important issue. Here, we review recent advances in methods for tracking and imaging extracellular vesicles in vivo and critically discuss their systemic distribution, targeting, and kinetics based on up-to-date evidence in the literature.
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