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Diffusion tensor imaging in children with tuberous sclerosis complex: tract-based spatial statistics assessment of
Anastasia K Zikou1, Vasileios G Xydis1, Loukas G Astrakas2
1Department of Radiology, Medical School, University of Ioannina, 1186, 45110, Ioannina, Greece.
Pediatric Radiology
|April 18, 2016
Summary
Children with tuberous sclerosis complex show altered white matter tracts. Diffusion tensor imaging (DTI) reveals increased axial diffusivity, suggesting reduced axonal integrity in these major brain pathways.
Area of Science:
- Neuroimaging
- White Matter Disorders
- Pediatric Neurology
Background:
- Microstructural changes in normal-appearing white matter are observed in tuberous sclerosis complex (TSC).
- Understanding white matter alterations is crucial for TSC management.
Purpose of the Study:
- To assess major white matter tracts in pediatric TSC using diffusion tensor imaging (DTI).
- To investigate white matter integrity in children diagnosed with TSC.
Main Methods:
- Employed tract-based spatial statistics (TBSS) DTI analysis on 8 children with TSC and 8 controls.
- Utilized T1-weighted and diffusion-weighted imaging sequences.
- Compared diffusion indices between patient and control groups.
Main Results:
- Tract-based spatial statistics revealed increased axial diffusivity in multiple white matter tracts in children with TSC.
- No significant differences in fractional anisotropy, mean diffusivity, or radial diffusivity were found between groups.
- No changes in diffusion indices were observed in TSC patients from baseline to follow-up.
Conclusions:
- Pediatric TSC patients exhibit elevated axial diffusivity in key white matter tracts.
- This finding likely indicates compromised axonal integrity in the white matter of children with TSC.
Keywords:
Central nervous systemChildDiffusion tensor imagingMagnetic resonance imagingTract-based spatial statisticsTuberous sclerosis complexMore Related Videos
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