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Updated: Mar 22, 2026

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
Published on: September 8, 2023
Linear viscoelasticity - bone volume fraction relationships of bovine trabecular bone
Krishnagoud Manda1, Shuqiao Xie2, Robert J Wallace3
1School of Engineering, The University of Edinburgh, The King's Buildings, Edinburgh, EH9 3DW, UK. k.manda@ed.ac.uk.
Abstract:
Trabecular bone has been previously recognized as time-dependent (viscoelastic) material, but the relationships of its viscoelastic behaviour with bone volume fraction (BV/TV) have not been investigated so far. Therefore, the aim of the present study was to quantify the time-dependent viscoelastic behaviour of trabecular bone and relate it to BV/TV. Uniaxial compressive creep experiments were performed on cylindrical bovine trabecular bone samples ([Formula: see text]) at loads corresponding to physiological strain level of 2000 [Formula: see text]. We assumed that the bone behaves in a linear viscoelastic manner at this low strain level and the corresponding linear viscoelastic parameters were estimated by fitting a generalized Kelvin-Voigt rheological model to the experimental creep strain response. Strong and significant power law relationships ([Formula: see text]) were found between time-dependent creep compliance function and BV/TV of the bone. These BV/TV-based material properties can be used in finite element models involving trabecular bone to predict time-dependent response. For users' convenience, the creep compliance functions were also converted to relaxation functions by using numerical interconversion methods and similar power law relationships were reported between time-dependent relaxation modulus function and BV/TV.
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