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Muscle function in patients with primary hyperparathyroidism.

C Joborn1, J Rastad, E Stålberg

  • 1Department of Internal Medicine, University Hospital, Uppsala, Sweden.

Muscle & Nerve
|February 1, 1989
PubMed
Summary
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Patients with primary hyperparathyroidism exhibit reduced anterior tibial muscle function, showing lower twitch tension and force, potentially explaining fatigue and weakness symptoms.

Area of Science:

  • Neurology
  • Endocrinology
  • Physiology

Background:

  • Primary hyperparathyroidism (HPT) is a common endocrine disorder.
  • Muscle weakness and fatigue are common symptoms in HPT patients.
  • The underlying mechanisms of muscle dysfunction in HPT require further investigation.

Purpose of the Study:

  • To investigate and compare muscle contraction function in the anterior tibial muscle between patients with primary HPT and healthy controls.
  • To quantify differences in muscle twitch tension and force generation.

Main Methods:

  • Electrically stimulated and computer-analyzed muscle twitches were measured in the anterior tibial muscle.
  • 18 unselected patients with primary HPT and 20 healthy controls participated.
  • Muscle twitch tension (TT), contraction time, and half relaxation time were assessed.

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Main Results:

  • HPT patients demonstrated significantly lower muscle twitch tension compared to controls (76 +/- 24 N vs. 99 +/- 33 N).
  • At high-frequency stimulation (20 Hz), muscle force in HPT patients was 73% of that in controls.
  • No significant differences were observed in contraction time, half relaxation time, or twitch potentiation between groups.

Conclusions:

  • Primary hyperparathyroidism is associated with impaired anterior tibial muscle function.
  • Reduced muscle force and twitch tension in HPT patients likely contribute to symptoms of weakness and fatigue.
  • These findings highlight the systemic effects of HPT on skeletal muscle physiology.