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Treadmill Running and Rutin Reverse High Fat Diet Induced Cognitive Impairment in Diet Induced Obese Mice
1Zhongxiao Wan, PhD, Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou, 215123, P.R. China, (P) 0186-0512-65883159; (F) 0186-0512-65883159,
The Journal of Nutrition, Health & Aging
|April 23, 2016
Summary
Treadmill exercise and rutin improve cognitive deficits in diet-induced obese mice. These interventions modulate key molecules like BACE1 and p-STAT3, offering protective effects against cognitive dysfunction.
Area of Science:
- Neuroscience
- Pharmacology
- Exercise Physiology
Background:
- Diet-induced obesity (DIO) is linked to cognitive impairment and Alzheimer's disease (AD) pathology.
- Key molecular pathways, including those involving BACE1, IDE, STAT3, and CREB, are implicated in AD pathogenesis.
- Understanding interventions that can mitigate these effects is crucial for developing therapeutic strategies.
Purpose of the Study:
- To investigate the independent and combined effects of treadmill exercise and rutin on cognitive function and AD-related molecular markers in DIO mice.
- To assess the impact of these interventions on proteins such as IDE, BACE1, STAT3, CREB, PSD-95, and synaptophysin in the hippocampus and cortex.
Main Methods:
- C57BL/6J mice were fed a high-fat diet (HFD) and randomized into five groups: control, HFD, HFD + rutin, HFD + exercise, and HFD + exercise + rutin.
- Cognitive function was evaluated using the Morris water maze test.
- Protein expression levels of key molecules were measured in hippocampal and cortical tissues via western blotting.
Main Results:
- Both treadmill exercise and rutin intervention, individually and in combination, ameliorated HFD-induced cognitive deficits.
- In the cortex, HFD increased BACE1 and decreased p-STAT3 and PSD-95; exercise and rutin reversed these changes.
- Specific molecular changes were observed in the hippocampus, with elevated IDE and p-CREB in intervention groups.
Conclusions:
- Treadmill running and rutin intervention show promise in improving HFD-induced cognitive impairment.
- Modulation of p-STAT3, p-CREB, BACE1, IDE, and PSD-95 are identified as potential mechanisms underlying the protective effects.
- These findings suggest that exercise and rutin may serve as beneficial strategies against diet-induced cognitive dysfunction and AD pathology.
