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Published on: February 5, 2020
Managing Adverse Events With Immune Checkpoint Agents
Ramona Dadu1, Chrystia Zobniw, Adi Diab
1From the Departments of *Endocrine Neoplasia and Hormonal Disorders and †Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Abstract:
Immune checkpoint inhibitors (anti-cytotoxic T-lymphocyte antigen 4 and anti programmed cell death 1/programmed cell death 1 ligand antibodies) have shown impressive clinical activity in multiple cancer types. Despite achieving great clinical success, challenges and limitations of these drugs as monotherapy or various combinational strategies include the development of a unique set of immune-related adverse events (irAEs) that can be severe and even fatal. Therefore, identification of patients at risk, prevention, consistent communication between patients and medical team, rapid recognition, and treatment of irAEs are critical in optimizing treatment outcomes. This review focuses on the description of more common irAEs and provides a suggested approach for management of specific irAEs.
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