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Isolated Lung Perfusion System in the Rabbit Model
Published on: July 15, 2021
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Novel Technologies for Isolated Lung Perfusion: Beyond Lung Transplant
Marcelo Cypel1, Shaf Keshavjee1
1Division of Thoracic Surgery, Department of Surgery, Toronto General Hospital, UHN, University of Toronto, 200 Elizabeth Street, 9N-969, Toronto, Ontario M5G 2C4, Canada.
Thoracic Surgery Clinics
|April 27, 2016
Summary
Isolated lung perfusion (ILP) offers a method to assess donor lung viability and treat lung injuries ex vivo. This technique also shows promise for delivering high-dose chemotherapy to treat pulmonary metastases in vivo.
Area of Science:
- Cardiovascular and Respiratory System
- Surgical Oncology
Background:
- Isolated lung perfusion (ILP) is a technique explored in lung transplantation and thoracic oncology.
- ILP aids in assessing donor lung physiological integrity post-explantation.
- It is also investigated for ex vivo repair of injured donor lungs.
Purpose of the Study:
- To review the rationale, technical aspects, and clinical experience of in vivo lung perfusion.
- To explore ILP's potential in delivering high-dose chemotherapy for pulmonary metastases.
Main Methods:
- Review of experimental and clinical data on isolated lung perfusion.
- Focus on the technical considerations and application of in vivo lung perfusion.
Main Results:
- ILP serves as a tool for evaluating donor lung suitability.
- The technique is proposed for therapeutic interventions on donor lungs.
- In vivo lung perfusion is a strategy for targeted chemotherapy delivery.
Conclusions:
- Isolated lung perfusion has diverse applications in lung transplantation and oncology.
- Further research into in vivo lung perfusion may expand its clinical utility.
- The technique holds potential for treating pulmonary metastatic disease.
