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Updated: Mar 22, 2026
Isolated Lung Perfusion System in the Rabbit Model
Published on: July 15, 2021
Novel Technologies for Isolated Lung Perfusion: Beyond Lung Transplant
Marcelo Cypel1, Shaf Keshavjee1
1Division of Thoracic Surgery, Department of Surgery, Toronto General Hospital, UHN, University of Toronto, 200 Elizabeth Street, 9N-969, Toronto, Ontario M5G 2C4, Canada.
Isolated lung perfusion (ILP) has been examined and developed in lung transplantation and thoracic oncology research. In lung transplantation, ILP has been used to assess physiologic integrity of donor lungs after removal from the donor, and it has also been proposed as a method for active treatment and repair of injured unsuitable donor organs ex vivo. ILP is attractive as a concept to deliver high-dose chemotherapy to treat pulmonary metastatic disease, referred to as in vivo lung perfusion. This article focuses on the rationale, technical aspects, and experimental and clinical experience of in vivo lung perfusion. A perspective on the future application of these techniques is described.
Isolated lung perfusion (ILP) has been examined and developed in lung transplantation and thoracic oncology research. In lung transplantation, ILP has been used to assess physiologic integrity of donor lungs after removal from the donor, and it has also been proposed as a method for active treatment and repair of injured unsuitable donor organs ex vivo. ILP is attractive as a concept to deliver high-dose chemotherapy to treat pulmonary metastatic disease, referred to as in vivo lung perfusion. This article focuses on the rationale, technical aspects, and experimental and clinical experience of in vivo lung perfusion. A perspective on the future application of these techniques is described.
