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Platelet Transfusions in Patients with Hypoproliferative Thrombocytopenia: Conclusions from Clinical Trials and

Gemma L Crighton1, Lise J Estcourt2, Erica M Wood3

  • 1Department of Epidemiology and Preventive Medicine, The Alfred Centre, Monash University, Level 6, 99 Commercial Road, Melbourne, Victoria, 3181, Australia; Australian Red Cross Blood Service, 100-154 Batman Street, West Melbourne, Victoria, 3003, Australia; Royal Children's Hospital, Department of Haematology, 50 Flemington Road, Parkville, Victoria, 3052, Australia.

Hematology/Oncology Clinics of North America
|April 27, 2016
PubMed

Patients with hematologic malignancies frequently become thrombocytopenic as a result of their underlying malignancy or treatments, including cytotoxic chemotherapy and hematopoietic stem cell transplantation and are at increased risk of hemorrhage. Prophylactic platelet transfusions are aimed at preventing severe or life-threatening hemorrhage. This review summarizes recent evidence, including the need for prophylactic platelet transfusions, the optimal dose, platelet transfusion triggers, and risk factors for bleeding. It also discusses controversies surrounding platelet transfusions in this population.

Keywords:
Acute leukemiaBleedingChemotherapyHematopoietic stem cell transplantationPlatelet transfusionThrombocytopenia

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