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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Bone mineral disorder in chronic kidney disease: Klotho and FGF23; cardiovascular implications

Laura Salanova Villanueva1, Carmen Sánchez González1, José Antonio Sánchez Tomero1

  • 1Servicio de Nefrología, Hospital de La Princesa, Madrid, España.

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|April 28, 2016
PubMed

Insights

Cardiovascular disease is a major cause of death in chronic kidney disease patients. Bone mineral disorders, including new markers like FGF23 and klotho, may increase this risk.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Cardiovascular disease (CVD) is a leading cause of death in patients with chronic kidney disease (CKD).
  • Bone mineral metabolism disorders and inflammation are key contributors to increased cardiovascular risk in CKD.
  • Established biochemical markers (calcium, phosphorus, vitamin D, PTH) are linked to CVD risk in CKD.

Purpose of the Study:

  • To explore the potential role of novel bone mineral metabolism markers, FGF23 and klotho, in cardiovascular disease associated with chronic kidney disease.

Main Methods:

  • This study reviews existing literature on bone mineral metabolism and cardiovascular risk in CKD.
  • Analysis focuses on the association between FGF23, klotho, and cardiovascular outcomes.

Main Results:

  • Classical bone mineral parameters (phosphorus, calcium, vitamin D, PTH) are well-established contributors to CVD risk in CKD.
  • Emerging evidence suggests that FGF23 and klotho may also play a significant role in cardiovascular complications.

Conclusions:

  • Bone mineral metabolism markers, including novel ones like FGF23 and klotho, are critically implicated in the elevated cardiovascular risk observed in chronic kidney disease patients.

Keywords:
Cardiovascular riskChronic kidney diseaseEnfermedad renal crónicaFGF23KlothoRiesgo cardiovascular

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