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Symmetric ambulatory arterial stiffness index in the young

Minh B Nguyen1, Pamela Singer2, Fredrick Kaskel1

  • 1Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY, USA.

Journal of the American Society of Hypertension : JASH
|April 28, 2016
PubMed

Insights

The ambulatory arterial stiffness index (AASI) and symmetric AASI (s-AASI) are linked to blood pressure variability in children. Obesity impacts AASI, and BP variability independently affects both AASI and s-AASI.

Area of Science:

  • Pediatric Cardiology
  • Vascular Physiology
  • Hypertension Research

Background:

  • Arterial stiffness indices, including ambulatory arterial stiffness index (AASI) and symmetric AASI (s-AASI), are established markers in adults.
  • Their utility in pediatric populations, particularly concerning anthropometric and blood pressure (BP) measures, requires further investigation.

Purpose of the Study:

  • To assess the correlation of AASI and s-AASI with anthropometric and BP parameters in children.
  • To investigate the relationship between these indices and BP variability in a pediatric cohort.

Main Methods:

  • Retrospective analysis of 102 children (7-22 years) from a pediatric hypertension clinic undergoing 24-hour ambulatory blood pressure monitoring (ABPM).
  • Calculation of AASI (1 - regression slope of diastolic BP on systolic BP) and s-AASI.
  • Multivariable regression analysis to identify independent predictors of AASI and s-AASI.

Main Results:

  • Obese children exhibited significantly higher AASI values.
  • s-AASI demonstrated a correlation with systolic BP variability.
  • BP variability was found to be an independent correlate of both AASI and s-AASI.

Conclusions:

  • AASI and s-AASI in children are significantly influenced by BP variability.
  • The findings suggest a potential role for these indices in pediatric hypertension, but further research is needed to confirm their clinical utility.

Keywords:
AASIhypertensionobesitypediatrics

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