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In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
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Related Experiment Video

Updated: Mar 22, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
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Therapeutic uses for Angiotensin-(1-7).

Alice Machado-Silva1, Danielle Passos-Silva2, Robson Augusto Santos2

  • 1a Fundação Oswaldo Cruz , Centro de Desenvolvimento Tecnológico em Saúde (CDTS) , Rio de Janeiro , Brazil.

Expert Opinion on Therapeutic Patents
|April 29, 2016
PubMed
Summary

Angiotensin-(1-7) shows significant therapeutic potential, as evidenced by numerous patents and clinical trials. This peptide offers promising treatments for various conditions, including cancer and cardiovascular diseases.

Keywords:
Angiotensin (1-7)Arg0Mas receptorPanCyteRASTXA-127

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Area of Science:

  • Pharmacology
  • Biochemistry
  • Medical Science

Background:

  • Angiotensin-(1-7) is a crucial peptide within the Renin-Angiotensin System.
  • It counter-regulates detrimental effects mediated by angiotensin II.
  • Its therapeutic potential is recognized and detailed in patent literature.

Purpose of the Study:

  • To review and summarize the therapeutic applications of Angiotensin-(1-7).
  • To highlight evidence from patent documents supporting its clinical use.
  • To assess the breadth of pathologies targeted by Angiotensin-(1-7).

Main Methods:

  • Comprehensive review of patent documents and applications.
  • Analysis of experimental evidence supporting therapeutic claims.
  • Synthesis of findings related to Angiotensin-(1-7) efficacy.

Main Results:

  • A wide array of therapeutic uses for Angiotensin-(1-7) are documented in patents.
  • Experimental data supports the efficacy of Angiotensin-(1-7) in various preclinical models.
  • Cancer treatment emerges as a highly advanced therapeutic area.

Conclusions:

  • The extensive patent landscape and ongoing clinical trials underscore the therapeutic promise of Angiotensin-(1-7).
  • Clinical studies demonstrate its potential in treating cardiovascular, hematological, and other conditions.
  • Angiotensin-(1-7) is a peptide with broad clinical applicability across multiple medical fields.