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Updated: Mar 22, 2026
Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
A CASE OF UNILATERAL RETINAL PIGMENT EPITHELIUM DYSGENESIS
Atsushi Yamasaki1, Takeshi Tominaga, Ryoko Ishikura
1Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, Tottori, Japan.
Purpose:
To report a case of unilateral retinal pigment epithelium dysgenesis.
Methods:
An 8-year-old boy with a large grayish lesion and leopard-spot pattern lesion at its periphery in his left eye underwent fluorescein angiography, fundus autofluorescence imaging, optical coherence tomography, and electroretinography.
Results:
Fluorescein angiography showed an area of geographic hyperfluorescence with a peripheral pattern of dark spots. The area of retinal pigment epithelial atrophy showed hypofluorescence on fundus autofluorescence. Optical coherence tomography of the left eye showed attenuation of the inner segment-outer segment junction and choroidal thinning. Single-flash electroretinography and scotopic electroretinography showed normal results and did not differ between both the eyes. The 30-Hz flicker test and photopic electroretinography showed a decrease in amplitude in the left eye.
Conclusion:
Unilateral retinal pigment epithelium dysgenesis is very rare, and its prognosis is still unknown. Careful follow-up of the patient seems to be essential.
