Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Computed Tomography01:10

Computed Tomography

9.4K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
9.4K
Positron Emission Tomography01:29

Positron Emission Tomography

8.0K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
8.0K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

738
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
738

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The discovery and forensic investigation of two early medieval burials.

Legal medicine (Tokyo, Japan)·2026
Same author

Dual-enhanced fluorescent biosensors using metal-coated piezoelectric nanoimprinted substrates.

Physical chemistry chemical physics : PCCP·2026
Same author

A practical guide to working with nanopipettes.

The Analyst·2025
Same author

Review of GPU-based Monte Carlo simulation platforms for transmission and emission tomography in medicine.

Physics in medicine and biology·2025
Same author

Baseline isotopic variability in plants and animals and implications for the reconstruction of human diet in 1 st century AD Pompeii.

Scientific reports·2025
Same author

Understanding Sensitivity in Nanoscale Sensing Devices.

ACS measurement science au·2025

Related Experiment Video

Updated: Mar 22, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.2K

A Fast Experimental Scanner for Proton CT: Technical Performance and First Experience with Phantom Scans.

Robert P Johnson1, Vladimir Bashkirov2, Langley DeWitt3

  • 1Santa Cruz Institute for Particle Physics and Physics Department, University of California at Santa Cruz, Santa Cruz, CA 95064, rjohnson@ucsc.edu.

IEEE Transactions on Nuclear Science
|April 30, 2016
PubMed
Summary

A new proton computed tomography (pCT) scanner accurately measures proton stopping power for head-sized objects. This innovation supports proton therapy planning and verification in cancer treatment.

Keywords:
Biomedical imagingCalorimetryComputed tomographyData acquisitionParticle trackingReconstruction algorithmsSilicon radiation detectors

More Related Videos

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
06:33

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Published on: July 29, 2013

11.8K
Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

800

Related Experiment Videos

Last Updated: Mar 22, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.2K
Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
06:33

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Published on: July 29, 2013

11.8K
Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

800

Area of Science:

  • Medical Physics
  • Imaging Technology
  • Radiation Oncology

Background:

  • Proton therapy offers precise radiation delivery but requires accurate treatment planning.
  • Current imaging methods may not fully capture proton interactions within tissues.
  • Advanced imaging techniques are needed for enhanced proton therapy verification.

Purpose of the Study:

  • To report the design, fabrication, and initial performance of a novel tomographic scanner for proton computed tomography (pCT).
  • To evaluate the scanner's capability for imaging head-sized objects for proton therapy applications.
  • To assess the accuracy of reconstructed proton relative stopping power in various materials.

Main Methods:

  • Developed a pCT scanner using silicon-strip telescopes and a multistage scintillation detector to track protons and measure their residual energy and range.
  • Derived water equivalent path length (WEPL) from measured proton data.
  • Employed an iterative, parallelizable reconstruction algorithm on GP-GPU hardware for image reconstruction.
  • Utilized 200 MeV protons from medical synchrotrons for scanner calibration and phantom testing.

Main Results:

  • Successfully calibrated the pCT instrument, including tracker alignment and WEPL calibration.
  • Achieved high data acquisition rates exceeding one million protons per second.
  • Completed full 360° scans in under 10 minutes.
  • Demonstrated accurate reconstruction of proton relative stopping power using a CATPHAN 404 phantom.

Conclusions:

  • The developed pCT scanner is a viable tool for preclinical imaging of head-sized objects.
  • The scanner's performance supports its intended use in proton therapy treatment planning and verification.
  • The technology shows promise for improving the precision and safety of particle-beam therapy.