Related Experiment Video

Updated: Mar 22, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

945

The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined

Lei Jin1, Wei-Ren Liu1, Meng-Xin Tian1

  • 1Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, 180 FengLin Road, Shanghai, 200032, China.

World Journal of Surgical Oncology
|May 1, 2016
PubMed

Insights

The sphingosine kinase/sphingosine-1-phosphate (S1P)/S1P receptor 1 (S1PR1) axis significantly impacts immunity and cancer. This review explores its functions and the therapeutic potential of targeting S1P signaling in cancer treatment.

Area of Science:

  • Biochemistry and Molecular Biology
  • Immunology
  • Oncology

Background:

  • Sphingosine and its metabolites play crucial roles in cellular signaling.
  • Recent research has elucidated complex pathways involving sphingosine metabolism.
  • The Sphingosine Kinase (SphK)/Sphingosine-1-Phosphate (S1P)/S1P Receptor 1 (S1PR1) axis is a key signaling pathway.

Purpose of the Study:

  • To review recent advances in understanding the SphKs/S1P/S1PR1 axis.
  • To discuss the role of this axis in immune responses.
  • To explore the involvement of this axis in cancer development and progression.

Main Methods:

  • Literature review of recent research.
  • Analysis of studies on the SphKs/S1P/S1PR1 pathway.
  • Investigation of therapeutic strategies targeting S1P signaling.

Main Results:

  • The SphKs/S1P/S1PR1 axis is integral to immune cell function and trafficking.
  • Dysregulation of this axis is implicated in various cancers.
  • Emerging drugs targeting S1P signaling show promise in preclinical cancer models.

Conclusions:

  • The SphKs/S1P/S1PR1 axis is a critical regulator of immunity and cancer.
  • Targeting S1P signaling represents a promising therapeutic avenue for cancer treatment.
  • Further research is warranted to fully exploit the therapeutic potential of S1P modulators.
Keywords:
CancerImmunitySphKs/S1P/S1PR1

More Related Videos

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

4.0K
A 3D Spheroid Model as a More Physiological System for Cancer-Associated Fibroblasts Differentiation and Invasion In Vitro Studies06:27

A 3D Spheroid Model as a More Physiological System for Cancer-Associated Fibroblasts Differentiation and Invasion In Vitro Studies

Published on: August 8, 2019

9.7K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.8K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.3K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

4.2K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
608
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
6.1K