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Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male
Patricia Freitas Corradi1, Renato B Corradi2, Loren Wissner Greene3
1Division of Endocrinology, New York University School of Medicine, 650 First Avenue, 7th Floor, New York, NY 10016, USA.
Abstract:
Testosterone synthesis and male fertility are the results of the perfect coordination of the hypothalamic-pituitary-gonadal axis. A negative feedback finely controls the secretion of hormones at the 3 levels. Congenital or acquired disturbance at any level leads to an impairment of reproductive function and the clinical syndrome of hypogonadism. In some cases, this condition is reversible. Once the diagnosis is made, testosterone replacement therapy is the standard therapy; however, novel therapies may improve spermatogenesis while elevating testosterone levels.
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