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Updated: Mar 21, 2026

A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
[Olfactory disorders – history, classification and implications]
11 Hals-Nasen-Ohrenklinik, Universitätsspital Basel.
Smell disorders are prevalent, increasing with age. Comprehensive olfactory testing is crucial for accurate diagnosis and management of these conditions.
Area of Science:
- Otorhinolaryngology
- Neuroscience
- Gerontology
Context:
- Smell disorders affect 3-5% of those under 65, rising to over 50% in the elderly.
- Self-assessment of smell is unreliable, necessitating objective olfactory testing.
- Sinunasal conditions are the most frequent cause of smell dysfunction.
Purpose:
- To highlight the prevalence and diagnostic challenges of smell disorders.
- To emphasize the importance of psychophysical olfactory testing, like the Sniffin' Sticks Test.
- To outline classification methods including clinical examination, imaging, and neurological assessment.
Summary:
- Olfactory testing is mandatory for diagnosing smell disorders, differentiating between quantitative and qualitative types.
- The Sniffin' Sticks Test battery provides detailed psychophysical assessment, classifying function as normosmia, hyposmia, or anosmia.
- Further investigations like MRI, CT scans, and neurological exams aid in identifying underlying causes, including neurodegenerative diseases.
Impact:
- Accurate diagnosis of smell disorders improves patient management and quality of life.
- Identifying olfactory dysfunction in the elderly may indicate reduced regeneration capacity and increased mortality risk.
- This research underscores the need for systematic olfactory evaluation in clinical practice.
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