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Familial iris melanosis--a misnomer?
1Department of Ophthalmology, Eye and Ear Infirmary, University of Illinois College of Medicine, Chicago.
The British Journal of Ophthalmology
|April 1, 1989
Summary
Iris melanosis, characterized by pigmented elevations on the iris, was observed in children from two families. This study suggests a potential link between iris melanosis and ocular hypertension.
Area of Science:
- Ophthalmology
- Genetics
- Dermatology
Background:
- Iris melanosis presents as minute, pigmented elevations on the anterior iris surface.
- This condition is typically considered rare and sporadic.
Purpose of the Study:
- To report familial cases of isolated iris melanosis.
- To investigate a potential association between iris melanosis and ocular hypertension.
Main Methods:
- Clinical examination of two unrelated Mexican families.
- Bilateral assessment of iris and ocular health.
- Evaluation for associated ocular or cutaneous findings.
Main Results:
- All affected children in both families presented with bilateral iris melanosis.
- No parental transmission of the condition was observed.
- Some family members exhibited signs suggestive of ocular hypertension.
- No other significant ocular or cutaneous pigmentary abnormalities were noted, except for a single thigh nevus.
Conclusions:
- This is the first report of familial iris melanosis with multiple affected siblings.
- The findings suggest a possible genetic component or predisposition to iris melanosis.
- A potential association between iris melanosis and ocular hypertension warrants further investigation.
- The term 'melanosis' may be inaccurate, as the condition involves elevations rather than diffuse hyperpigmentation.