Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

6.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
6.4K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

8.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.8K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.3K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.3K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

1.4K
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.4K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

643
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
643
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ferroptosis-Associated Fibroblast Activation and Transcriptional Remodelling in Human Heart Failure: A Proof-of-Concept Study.

European journal of clinical investigation·2026
Same author

Ferroptosis in heart failure: from molecular insights to therapeutic implications.

Cardiovascular research·2026
Same author

Hellenic Postprandial Lipemia Study (HPLS): A Prospective Cohort Trial on the Effect of Statins on Postprandial Hypertriglyceridemia.

Current vascular pharmacology·2026
Same author

Aortic Stenosis Prevention: Is a New Cardiovascular Disease Paradigm Coming of Age?

Journal of clinical medicine·2025
Same author

Polycystic Ovary Syndrome and Ferroptosis: Following Ariadne's Thread.

Biomedicines·2024
Same author

Non-Hereditary Obesity Type Networks and New Drug Targets: An In Silico Approach.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Mar 21, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.8K

Thyroid hormones and cardiac remodeling.

Dennis V Cokkinos1,2, Stavros Chryssanthopoulos3

  • 1Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou St., 115 27, Athens, Greece. dcokkinos@bioacademy.gr.

Heart Failure Reviews
|May 4, 2016
PubMed
Summary
This summary is machine-generated.

Thyroid hormones, particularly T3, offer heart protection by acting on specific receptors. These hormones demonstrate anti-remodeling properties, crucial for cardiovascular health.

Keywords:
Cardiac remodelingDIPTAMyocardial infarctionThyroid hormonesThyroid receptors

More Related Videos

Isolation and Physiological Analysis of Mouse Cardiomyocytes
11:02

Isolation and Physiological Analysis of Mouse Cardiomyocytes

Published on: September 7, 2014

24.1K
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.7K

Related Experiment Videos

Last Updated: Mar 21, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.8K
Isolation and Physiological Analysis of Mouse Cardiomyocytes
11:02

Isolation and Physiological Analysis of Mouse Cardiomyocytes

Published on: September 7, 2014

24.1K
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.7K

Area of Science:

  • Cardiology
  • Endocrinology
  • Molecular Biology

Background:

  • Thyroid hormones exert significant cardioprotective effects.
  • These actions are mediated primarily by triiodothyronine (T3) binding to thyroid receptors alpha1 (α1) and beta1 (β1).
  • Thyroid hormones possess procontractile, anti-apoptotic, anti-inflammatory, and anti-fibrotic properties.

Purpose of the Study:

  • To provide an overview of the cardioprotective and anti-remodeling actions of thyroid hormones.
  • To summarize findings from both animal and human studies regarding thyroid hormone effects on the heart.
  • To define cardiac remodeling in the context of heart disease.

Main Methods:

  • Review of existing animal studies, primarily in rodents, investigating thyroid hormone effects on cardiac structure and function.
  • Analysis of clinical studies, including those in patients with dilated ischemic cardiomyopathy (DIPTA), to assess human relevance.
  • Examination of the specific impact of thyroid hormones on the cardiac border zone.

Main Results:

  • Thyroid hormones promote angiogenesis, regeneration, and exhibit beneficial effects on microRNA profiles.
  • Numerous animal studies demonstrate anti-remodeling effects of thyroid hormones.
  • Clinical studies in humans, specifically in DIPTA, have provided conclusions on these effects.

Conclusions:

  • Thyroid hormones, acting via T3 receptors, offer multifaceted cardioprotection.
  • Evidence from animal and human studies supports the anti-remodeling role of thyroid hormones in the heart.
  • Understanding these mechanisms is vital for developing therapeutic strategies for heart conditions characterized by remodeling.