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Published on: November 10, 2013
Synthesis and Anticancer Study of Novel 4H-Chromen Derivatives
Xiaolin Lu1, Gaochao Dong2, Ying Zheng1
1Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiang Su, 211198, China.
Objective/Method:
A series of 4H-chromen-4-one derivatives (A1-A16) have been designed and synthesized, and they were screened for BRAF kinase inhibitory activity. Furthermore, their biological activities were evaluated in vitro.
Result:
Compounds A03 and A10 displayed the most potent antiproliferative activity against human osteosarcoma cell line (U2OS) and A16 displayed the most potent antiproliferative activity against human melanoma cancer cell line (A375) in vitro, which was valuable to study further.
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