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Updated: Mar 21, 2026

Author Spotlight: Separation of Coral Host Tissues and Algal Symbionts and Analyzing Their Metabolites
Published on: October 13, 2023
Steroid constituents from the soft coral Sinularia microspiculata
Nguyen Van Thanh1, Ninh Thi Ngoc1, Hoang Le Tuan Anh1
1a Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
Abstract:
A methanol extract of the soft coral Sinularia microspiculata revealed five sterols, including two new compounds. Using combined chromatographic and spectroscopic experiments, the new compounds were found to be 7-oxogorgosterol (1) and 16α-hydroxysarcosterol (2). Their structures were determined on the basis of spectroscopic data ((1)H and (13)C NMR, HSQC, HMBC, (1)H-(1)H COSY, NOESY, and FT-ICR-MS) and by comparing obtained results to the values indicated in previous studies. Among the isolated compounds, 3 showed weak cytotoxic effects against HL-60 (IC50 = 89.02 ± 9.93 μM) cell line, whereas 5 was weakly active against HL-60 (IC50 = 82.80 ± 13.65 μM) and SK-Mel2 (IC50 = 72.32 ± 1.30 μM) cell lines.
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