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Physically crosslinked-sacran hydrogel films for wound dressing application.
Nasrul Wathoni1, Keiichi Motoyama2, Taishi Higashi2
1Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan; Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Summary
Sacran hydrogel films show promise for wound healing. These novel polysaccharide films offer superior hydration and wound healing properties compared to sodium alginate, with no observed cytotoxicity.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Wound Healing Research
Background:
- Hydrogel films from polysaccharides are explored for biomedical applications, particularly wound healing.
- Natural polysaccharides are gaining attention for wound dressing development.
Purpose of the Study:
- To prepare and characterize a novel physically crosslinked-hydrogel film from sacran for wound dressing applications.
- To evaluate the performance of sacran hydrogel films in comparison to sodium alginate films.
Main Methods:
- Fabrication of a physically crosslinked-sacran hydrogel film using a solvent-casting method.
- Characterization of hydrogel film properties, including thickness and swelling ratio.
- Cytotoxicity assessment on NIH3T3 cells.
- In vivo skin hydration and wound healing studies on hairless mice.
Main Results:
- A thin, physically crosslinked-sacran hydrogel film was successfully fabricated.
- Sacran hydrogel films exhibited a high swelling ratio (19-fold) and superior structural integrity compared to sodium alginate films.
- No cytotoxicity was observed on NIH3T3 cells.
- In vivo studies showed increased skin hydration and improved wound healing with sacran hydrogel films.
Conclusions:
- Sacran hydrogel films demonstrate excellent hydration and wound healing capabilities.
- The observed benefits are likely due to sacran's moisturizing and anti-inflammatory effects.
- Sacran shows potential as a foundational biomaterial for advanced wound dressing applications.
