Modeling and Simulation of 4D PET-CT and PET-MR Images

The driving force in the research and development of new hybrid PET-CT/MR imaging scanners is the production of images with optimum quality, accuracy, and resolution. However, the acquisition process is limited by several factors. Key issues are the respiratory and cardiac motion artifacts that occur during an imaging session. In this article the necessary tools for modeling and simulation of realistic high-resolution four-dimensional PET-CT and PET-MR imaging data are described. Beyond the need for four-dimensional simulations, accurate modeling of the acquisition process can be included within the reconstruction algorithms assisting in the improvement of image quality and accuracy of estimation of physiologic parameters from four-dimensional hybrid PET imaging.