PET for Therapeutic Response Monitoring in Oncology

After diagnosis and staging of cancer, the most important process in modern oncology is assessment of therapeutic response. Timely identification of patients with poor response may allow introduction of alternative therapies, sparing patients the toxicity of ineffective treatments, reducing health care cost, and potentially delivering better outcomes. Metabolic imaging using PET is increasingly recognized as providing earlier and more robust assessment than conventional imaging. There are now ample clinical data indicating that PET metabolic response should be strongly considered for inclusion in evaluation of clinical response in individual high-risk malignancies to both direct the care of individual patients and to guide application of new therapies in particular cancer populations.