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The codrug approach for facilitating drug delivery and bioactivity
Ibrahim A Aljuffali1, Chwan-Fwu Lin2, Chun-Han Chen3,4
1a Department of Pharmaceutics , College of Pharmacy, King Saud University , Riyadh , Saudi Arabia.
Expert Opinion on Drug Delivery
|May 10, 2016
Summary
Codrugs chemically link multiple drugs to enhance therapeutic benefits like solubility and permeation, while potentially reducing toxicity. This review explores their history, design, and applications in treating various disorders.
Area of Science:
- Medicinal Chemistry
- Pharmacology
- Drug Delivery
Background:
- Codrugs are chemically linked multiple drugs designed to improve therapeutic efficiency and reduce adverse effects.
- They can be cleaved in vivo to release active parent drugs, offering advantages over conventional drugs.
Purpose of the Study:
- To review the history, design strategies, and potential applications of codrugs.
- To systematically introduce the chemical and enzymatic hydrolysis, bioactivity, and pharmacokinetics of codrugs.
Main Methods:
- Literature review of codrug research, design, and applications.
- Systematic introduction of hydrolysis, bioactivity, and pharmacokinetic properties.
Main Results:
- Codrugs offer enhanced solubility, increased permeation across biomembranes, prolonged half-life, and reduced toxicity.
- Applications span neurodegenerative, cardiovascular, cancerous, infectious, and inflammatory disorders.
Conclusions:
- Codrug design can improve drug transport, bioavailability, and targeted delivery.
- Optimization is crucial to balance delivery enhancement with potential toxicity.