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Updated: Mar 21, 2026

Targeting Biofilm Associated Staphylococcus aureus Using Resazurin Based Drug-susceptibility Assay
Published on: May 5, 2016
Random peptide mixtures inhibit and eradicate methicillin-resistant Staphylococcus aureus biofilms
Tal Stern1, Einat Zelinger, Zvi Hayouka
1Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel. zvi.hayouka@mail.huji.ac.il.
Abstract:
Methicillin-resistant Staphylococcus aureus (MRSA) is a biofilm-forming pathogen that can cause serious health complications in humans, ranging from minor to life-threatening infections. The challenge of successfully combating biofilms requires the discovery of compounds with a novel mode of action. We have recently developed sequence-random hydrophobic-cationic peptides that display a broad antibacterial activity. In the current study we show that our novel compounds are capable of controlling and managing MRSA biofilms and might be used as lead biofilm inhibitor candidates for further studies.
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