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Choroidal Caverns: A Novel Optical Coherence Tomography Finding in Geographic Atrophy
Giuseppe Querques1, Eliana Costanzo2, Alexandra Miere2
1Department of Ophthalmology University Paris Est Creteil, Centre Hospitalier Intercommunal de Creteil, Creteil, France 2Department of Ophthalmology, University Scientific Institute San Raffaele, Milan, Italy.
Investigative Ophthalmology & Visual Science
|May 11, 2016
Summary
Choroidal caverns are a rare finding in geographic atrophy (GA) secondary to age-related macular degeneration (AMD). These OCT-identified cavities appear in non-perfused areas of the choroid.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD).
- Optical coherence tomography (OCT) is crucial for visualizing retinal and choroidal structures.
Purpose of the Study:
- To describe and interpret choroidal caverns, a novel OCT finding in patients with GA.
- To determine the prevalence and characteristics of these caverns.
Main Methods:
- Retrospective analysis of 120 patients with GA.
- Multimodal imaging including OCT, OCT-Angiography, and Indocyanine angiography.
- Review of medical records to assess cavern prevalence and localization.
Main Results:
- Choroidal caverns were found in 17 eyes (15 patients) with GA, with an estimated prevalence of 12.5%.
- These caverns appeared as hyporeflective cavities in the Sattler and Haller layers, often with internal hyperreflectivities.
- OCT-Angiography confirmed these areas lacked perfused choroidal vessels.
Conclusions:
- Choroidal caverns are an infrequent finding in GA associated with AMD.
- They present as unique cavities in non-perfused choroidal areas.
- Possible origin from nonperfused ghost vessels and stromal remnants is suggested.
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