Related Experiment Video
Updated: Mar 21, 2026
A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration
Published on: March 10, 2023
LAMELLAR HOLE-ASSOCIATED EPIRETINAL PROLIFERATION: A Clinicopathologic Correlation
Claudine E Pang1, David A Maberley, K Bailey Freund
1*Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada; †Vitreous Retina Macula Consultants of New York, New York, New York; ‡LuEsther T. Mertz Retinal Research Center, Manhattan Eye Ear and Throat Hospital, New York, New York; §Department of Ophthalmology, New York University School of Medicine, New York, New York; and ¶Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Surgical excision of lamellar hole-associated epiretinal proliferation (LHEP) in eyes with lamellar macular holes led to closure and improved vision. LHEP contains retinal glial cells, suggesting Müller cell origin.
Area of Science:
- Ophthalmology
- Retinal Surgery
- Histopathology
Background:
- Lamellar macular holes (LMH) associated with epiretinal proliferation (LHEP) present unique surgical challenges.
- Understanding the cellular composition of LHEP is crucial for elucidating its pathogenesis.
Observation:
- A case of LMH with LHEP underwent pars plana vitrectomy with internal limiting membrane peeling.
- Spectral-domain optical coherence tomography confirmed LMH closure post-surgery.
- Histopathological analysis of excised LHEP revealed glial cells positive for GFAP and glutamine synthetase.
Findings:
- Successful surgical closure of LMH with LHEP was achieved.
- Significant visual acuity improvement from 20/200 to 20/40 was observed.
- Immunohistochemistry identified Müller cells within the LHEP specimen.
Implications:
- Pars plana vitrectomy with ILM peeling is effective for LMH with LHEP.
- LHEP may originate from Müller cells within the retinal glial component of the lamellar defect.
- Further research into LHEP pathogenesis can guide treatment strategies for macular holes.
More Related Videos
06:15Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
10:14Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023