Related Experiment Video
Updated: Mar 21, 2026
08:18
Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model
Published on: February 8, 2022
3.1K
"Solid Red Line": An Observational Study on Death from Refractory Intracranial Hypertension
M Czosnyka1, M Aries2, C Weersink2
1Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Acta Neurochirurgica. Supplement
|May 12, 2016
Summary
A "solid red line" in cerebrovascular pressure reactivity (PRx) monitoring, indicating PRx > 0.3, signals severe brain blood flow deterioration. This visual cue can precede dangerous intracranial pressure increases in traumatic brain injury patients.
Area of Science:
- Neuroscience
- Critical Care Medicine
- Neurological Surgery
Background:
- Cerebrovascular pressure reactivity (PRx) is a key outcome predictor after traumatic brain injury (TBI).
- PRx is typically noisy in the time domain, complicating interpretation.
- Color-coded PRx (green <0, red >0.3) on ICM+ aids visualization.
Purpose of the Study:
- To investigate the significance of a sustained
Main Methods:
- Retrospective analysis of 21 patients (20 TBI, 1 SAH) from 6 European/Australian centers.
- All patients experienced refractory intracranial hypertension and died.
- ICP and PRx data were monitored, focusing on the "solid red line" (PRx > 0.3) phenomenon.
Main Results:
- A "solid red line" in PRx preceded increases in intracranial pressure (ICP) above 25 mmHg in all cases.
- This warning period ranged from minutes to hours, and up to 2-3 days in two cases.
- Initial ICP was often <20 mmHg, rising above 60 mmHg, with cerebral perfusion pressure <20 mmHg.
Conclusions:
- A prolonged "solid red line" (PRx > 0.3) is a critical indicator of deep cerebrovascular deterioration.
- This visual pattern may offer a crucial early warning for impending intracranial hypertension crises.
- Enhanced PRx monitoring can improve clinical management in severe TBI and SAH.
