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Updated: Mar 21, 2026

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Palmar-plantar erythrodysesthesia: An uncommon adverse effect of everolimus
Shalabh Arora1, Rajendra Akhil1, Raju Titus Chacko1
1Department of Medical Oncology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Abstract:
Mammalian target of rapamycin inhibitor everolimus is a novel agent used in endocrine therapy resistant hormone receptor positive metastatic breast cancer. Its use has been associated with clinically significant improvement in the otherwise dismal outcomes of this subset of patients. Rash is a common adverse effect associated with everolimus. However, Hand-foot syndrome is an uncommon toxicity with the use of this drug. We report a case of Grade 3 hand-foot syndrome following institution of everolimus therapy and describe its successful management.
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