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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
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[Evolution and phylogeny of B lymphocytes].
Fabiola Claudio-Piedras1, Humberto Lanz-Mendoza
1Centro de Investigaciones sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Secretaría de Salud, Cuernavaca, Morelos, México. humberto@insp.mx.
Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|May 14, 2016
Summary
The evolution of B lymphocytes, key immune cells in mammals, traces back to fish. This review explores invertebrate immune components, revealing how their properties converged to form the B lymphocyte.
Area of Science:
- Immunology
- Evolutionary Biology
- Comparative Biology
Background:
- B lymphocytes are crucial for mammalian adaptive immunity.
- The evolutionary origins of B lymphocytes remain largely unknown.
- B lymphocytes first appeared in fish, suggesting an ancient evolutionary history.
Purpose of the Study:
- To analyze the principal components of invertebrate immune responses.
- To investigate the phylogenetic distribution of immune properties.
- To understand the emergence of B lymphocytes through invertebrate immunity.
Main Methods:
- Review of existing literature on invertebrate and vertebrate immunology.
- Phylogenetic analysis of immune system components.
- Comparative study of immune cell functions across different taxa.
Main Results:
- Many B lymphocyte characteristics are distributed among invertebrates.
- Specific immune properties found in invertebrates converged to form the B lymphocyte.
- The study highlights the ancient origins and evolutionary trajectory of B cells.
Conclusions:
- B lymphocytes evolved from components present in invertebrate immune systems.
- An evolutionary and multidisciplinary approach is essential for studying B lymphocyte origins and functions.
- Understanding B cell evolution provides insights into mammalian immunity.
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