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3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography
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Morphometric differences between central vs. surface acini in A/J mice using high-resolution micro-computed

Abhilash S Kizhakke Puliyakote1, Dragoş M Vasilescu2, John D Newell1

  • 1Department of Radiology, University of Iowa, Iowa City, Iowa; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa;

Journal of Applied Physiology (Bethesda, Md. : 1985)
|May 14, 2016
PubMed
Summary
This summary is machine-generated.

Surface acini in mouse lungs exhibit distinct structural differences compared to central acini, with larger diameters and increased branching. These findings highlight variations in pulmonary acinar geometry.

Keywords:
acinar structurecentral line-based morphometrylung parenchymapulmonary imagingquantitative CTsystematic uniform random sampling

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Area of Science:

  • Pulmonary anatomy and physiology
  • High-resolution imaging techniques
  • Morphometrics

Background:

  • Microcomputed tomography (μCT) enables non-destructive assessment of lung structures at high resolution.
  • Understanding acinar geometry is crucial for respiratory research.
  • Previous studies have not fully characterized differences between central and surface acini.

Purpose of the Study:

  • To characterize morphometric differences between central and surface pulmonary acini.
  • To determine if surface acini accurately reflect global acinar geometry.
  • To investigate structural variations in A/J mouse lungs.

Main Methods:

  • Used high-resolution microcomputed tomography (μCT) on ex vivo mouse lungs.
  • Applied systematic uniform random sampling (SURS) for identifying central and surface acini.
  • Assessed acinar morphometric metrics including diameters, lengths, branching angles, volume, and surface area.

Main Results:

  • Central acini showed smaller branch diameters and no significant increase in branch lengths per generation.
  • Surface acini displayed larger alveolar duct diameters, increased branching, and more terminal sacs.
  • Surface acini had greater total path lengths, volumes, and surface areas than central acini, with similar surface/volume ratios.

Conclusions:

  • Significant structural differences exist between central and surface acini in A/J mouse lungs.
  • Surface acini do not entirely reflect the global geometry of central acini.
  • These findings provide detailed insights into pulmonary acinar structural heterogeneity.