Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Immunological Memory

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

System of Memory

System of Memory

Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...

Working Memory

Working Memory

Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...

Long-Term Memory

Long-Term Memory

Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...

Traumatic Memory

Traumatic Memory

Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pathological perspectives on immune-related adverse events.

Immunological medicine·2026

Same author

Graded ankle instability induces early osteoarthritic changes in a rat model.

Osteoarthritis and cartilage open·2026

Same author

Immune microenvironment and strategy of immunotherapy in acral melanoma.

Immunological medicine·2026

Same author

Application of <i>In Vivo</i> Cryotechnique for Morphological Visualization of Nerve and Vascular Structures in a Sciatic Nerve Crush Model.

Acta histochemica et cytochemica·2026

Same author

Spatiotemporal dynamics of exercise-induced macrophages influences axonal regeneration after peripheral nerve injury.

Biomedical research (Tokyo, Japan)·2026

Same author

Solid Variant Aneurysmal Bone Cyst of the Trapezoid Bone: A Case Report.

The journal of hand surgery Asian-Pacific volume·2026

Search research articles

Related Experiment Video

Updated: Jan 25, 2026

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

Cancer immunotherapy and immunological memory.

Kenji Murata¹, Tomohide Tsukahara, Toshihiko Torigoe

¹Department of Pathology, Sapporo Medical University School of Medicine.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology

|May 17, 2016

Summary

Human T cell memory differs from mouse models and is crucial for cancer immunotherapy. Researchers identified a novel human memory T cell population with stem-like properties, offering potential for new cancer treatments.

More Related Videos

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

Related Experiment Videos

Last Updated: Jan 25, 2026

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

Area of Science:

Immunology
Cancer Research
Cell Biology

Background:

Human immunological memory is vital for adaptive immunity and infection control.
Existing mouse models of T cell memory differ significantly from the diverse human system.
Immunological memory in T cells is critical for effective cancer immunotherapy.

Purpose of the Study:

To elucidate the unique characteristics of the human T cell memory system.
To identify novel human T cell populations relevant for cancer immunotherapy.
To explore the potential of stem cell-like memory T cells in cancer treatment.

Main Methods:

Analysis of human T cell populations.
Characterization of T cell differentiation and memory states.
Investigation of chemoresistance properties in novel T cell populations.

Main Results:

A novel human memory T cell population was identified.
This population exhibits characteristics closer to naive T cells than previously known memory cells.
The novel cells possess stem-like chemoresistance properties.

Conclusions:

Human T cell memory is distinct and requires human-specific study.
The identified novel memory T cell population holds promise for cancer immunotherapy.
These findings support the development of peptide vaccination and adoptive cell transfer strategies using stem-like memory T cells.