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Related Concept Videos

Diabetes: Management and Pharmacotherapy01:15

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Diabetes Mellitus: Overview and Type I Subtype01:22

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Insulin: Dosing Regimen and Adverse Effects01:16

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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
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Diabetes: Symptoms, Diagnosis, and Complications01:15

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Pathophysiology of Diabetes01:20

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Weekend therapy in diabetes.

Sanjay Kalra1, Yashdeep Gupta2

  • 1Department of Endocrinology, Bharti Hospital, Karnal, AIIMS, New Delhi, India.

JPMA. the Journal of the Pakistan Medical Association
|May 18, 2016
PubMed
Summary
This summary is machine-generated.

Weekend therapy is now a reality for diabetes management. New injectable and oral medications offer convenient once-weekly dosing options for improved patient adherence and treatment outcomes.

Keywords:
Dulaglutide, Exenatide QW, Glucagon-like peptide 1 receptor agonists (GLP1RA), Semaglutide, Omarigliptin, Trelagliptin.

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Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Diabetes management requires consistent medication adherence.
  • Traditional daily dosing regimens can pose challenges for patient compliance.

Purpose of the Study:

  • To introduce the concept of "weekend therapy" for diabetes.
  • To review available and emerging once-weekly medications for diabetes treatment.

Main Methods:

  • Literature review of current and developmental diabetes medications.
  • Focus on drugs with once-weekly administration.

Main Results:

  • Several injectable and oral medications are available or in late-stage development for weekly use.
  • Examples include dulaglutide, exenatide QW, semaglutide, omarigliptin, and trelagliptin.

Conclusions:

  • Once-weekly diabetes therapies represent a significant advancement in treatment convenience.
  • These "weekend therapy" options have the potential to improve patient adherence and glycemic control.