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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Making the Least Reactive Electrophile the First in Class: Domino Electrophilic Activation of Amides
1Faculty of Chemistry, Institute of Organic Chemistry, University of Vienna , Währinger Strasse 38, 1090 Vienna, Austria.
Abstract:
The electrophilic activation of amides, especially by the action of trifluoromethanesulfonic (triflic) anhydride, enables the formation of highly electrophilic and reactive intermediates, lending themselves to diverse reaction pathways. This synopsis sets out to highlight recent advances in the field of amide activation, focused on the use of triflic anhydride, and the myriad of transformations that can ensue upon addition of several classes of electrophiles to the intermittently generated high energy intermediates.
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