Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glial Cells

Glial Cells

Nervous Tissue: Glial Cells

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

cIMPACT-NOW update 12: Refining Pathology-based Risk Stratification and Grading for IDH-mutant Gliomas.

Neuro-oncology·2026

Same author

Berzosertib enhances the sensitivity of pediatric diffuse midline glioma H3K27-altered cells to radiotherapy.

Cell death & disease·2026

Same author

Pediatric high-grade gliomas in patients with neurofibromatosis type 1-A collaborative cohort study from the SIOPE HGG/DIPG working group.

Neuro-oncology practice·2026

Same author

Detection of structural DNA variants in medulloblastomas using optical genome mapping.

Acta neuropathologica communications·2026

Same author

A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification.

Nature genetics·2026

Same author

Germline variants in ATM, BRCA2, other cancer predisposition and novel candidate genes are implicated in glioma risk in adult glioma patients with a familial or personal history of tumors.

Acta neuropathologica·2026

Same journal

Accidental hypothermia.

Nature reviews. Disease primers·2026

Same journal

Accidental hypothermia.

Nature reviews. Disease primers·2026

Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026

Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026

Same journal

Buruli ulcer in Africa: between innovation and pragmatism.

Nature reviews. Disease primers·2026

Same journal

Author Correction: Atopic dermatitis.

Nature reviews. Disease primers·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 21, 2026

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

Glioma.

Michael Weller¹, Wolfgang Wick², Ken Aldape³

¹Department of Neurology and Brain Tumor Center, University Hospital Zurich and University of Zurich, Frauenklinikstrasse 26, CH-8091 Zurich, Switzerland.

Nature Reviews. Disease Primers

|May 19, 2016

Summary

This summary is machine-generated.

New glioma classifications based on molecular profiling, like IDH mutations and 1p/19q co-deletion, improve prognosis prediction for adult brain tumors. Pediatric gliomas have distinct molecular features and better outcomes.

More Related Videos

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

Related Experiment Videos

Last Updated: Mar 21, 2026

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

Area of Science:

Neuro-oncology
Genomics
Molecular Pathology

Background:

Gliomas, primary brain tumors, traditionally classified by histology and WHO grade.
Recent advances in genomic, transcriptomic, and epigenetic profiling have revolutionized glioma classification.

Purpose of the Study:

To present updated concepts for classifying and treating gliomas based on molecular insights.
To differentiate adult and pediatric glioma classifications and their prognostic implications.

Main Methods:

Genomic, transcriptomic, and epigenetic profiling of gliomas.
Analysis of molecular subgroups in adult and pediatric populations.
Review of current and potential future treatment strategies.

Main Results:

Adult gliomas reclassified into three distinct molecular groups: IDH-mutant/1p/19q-co-deleted (best prognosis), IDH-mutant/1p/19q-non-co-deleted (intermediate), and IDH-wildtype (poor prognosis).
Pediatric gliomas are molecularly distinct, with pilocytic astrocytomas (WHO grade I) showing favorable prognosis and frequent BRAF alterations.
Ependymal tumors exhibit distinct epigenetic subgroups based on location and prognosis.

Conclusions:

Molecular classification significantly refines glioma prognosis and treatment stratification.
Tailored treatment strategies targeting specific molecular pathways and antigenic profiles hold promise for improved outcomes.