Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

74
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
74
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

179
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
179
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

83
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
83
Drug Delivery: Overview01:16

Drug Delivery: Overview

1.1K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.1K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

953
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
953
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

204
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
204

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient Misconceptions About Hyaluronic Acid Fillers: Experience-based Considerations.

Aesthetic surgery journal·2026
Same author

1927 nm Diode Laser for Infraorbital Hyperpigmentation in Skin of Color: Safe and Effective Approach.

Journal of drugs in dermatology : JDD·2026
Same author

Global Trends and Evidence Evaluation: A Systematic Review of Polynucleotide and Polydeoxyribonucleotide Therapy in Dermatology.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

Cutaneous Variations in Stem-Cell Population in Those on GLP1-Receptor Agonists: A Comparative Controlled Study.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

Regenerative Aesthetics: Present Advances and Emerging Strategies for Optimized Tissue Health.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

International Expert Consensus on Integrated Skincare Active Ingredients for Pretreatment and Posttreatment Use With Medical Aesthetic Procedures to Enhance Skin Benefits.

Journal of cosmetic dermatology·2026

Related Experiment Video

Updated: Mar 21, 2026

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
07:12

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Published on: September 27, 2021

2.8K

Laser-Assisted Drug Delivery.

Lisa Ann Zaleski-Larsen1, Sabrina G Fabi

  • 1*Department of Dermatology, Naval Medical Center San Diego, San Diego, California; †Cosmetic Laser Dermatology, San Diego, California.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|May 19, 2016
PubMed
Summary

Laser-assisted drug delivery (LADD) enhances topical medication and cosmeceutical skin penetration. Further research is needed to fully establish LADD's safety, efficacy, and optimal application protocols.

More Related Videos

An “All-laser” Endothelial Transplant
09:59

An “All-laser” Endothelial Transplant

Published on: July 6, 2015

10.0K
Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
07:47

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

9.6K

Related Experiment Videos

Last Updated: Mar 21, 2026

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
07:12

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Published on: September 27, 2021

2.8K
An “All-laser” Endothelial Transplant
09:59

An “All-laser” Endothelial Transplant

Published on: July 6, 2015

10.0K
Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
07:47

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

9.6K

Area of Science:

  • Dermatology
  • Biomedical Engineering
  • Pharmacology

Background:

  • Laser-assisted drug delivery (LADD) is an emerging therapeutic approach for targeted drug distribution within the skin.
  • LADD presents benefits including accessibility, non-invasiveness, patient compliance, safety, and efficacy.

Purpose of the Study:

  • To conduct a comprehensive review of the existing literature on Laser-assisted drug delivery (LADD).

Main Methods:

  • A systematic MEDLINE search was performed for studies on LADD published between 1989 and 2015.
  • The identified literature was summarized, and practical applications were discussed.

Main Results:

  • The review identified the use of ablative, nonablative, and fractional lasers to enhance cutaneous permeation of topical medications and cosmeceuticals.
  • Various topical treatments have been utilized with LADD, highlighting the need for further investigation.

Conclusions:

  • This review provides a comprehensive overview of LADD in the current literature.
  • Additional studies are required to thoroughly assess LADD's safety, optimal dosing, potential side effects, and overall effectiveness.